Abstract
Background context
Analgesic effect of lidocaine infusion on postoperative pain.
Purpose
The aim of this study was to evaluate the analgesic effect of lidocaine infusion on
postoperative pain after lumbar microdiscectomy.
Study design
This study used a prospective, randomized, double-blinded, and placebo-controlled
clinical trial.
Patient sample
Fifty-one patients participated in this randomized, double-blinded study.
Outcome measures
The primary outcome was the visual analog scale (VAS) (0–100 mm) pain score at 4 hours
after surgery. The secondary outcomes were the VAS pain score at 2, 8, 12, 24, and
48 hours after surgery, the frequency with which patients pushed the button (FPB)
of the patient-controlled analgesia system, and the fentanyl consumption at 2, 4,
8, 12, 24, and 48 hours after surgery. Other outcomes were satisfaction scores regarding
pain control and the overall recovery process, incidence of postoperative nausea and
vomiting (PONV), and length of hospital stay (HS).
Methods
Preoperatively and throughout the surgery, Group L received intravenous lidocaine
infusion (a 1.5-mg/kg bolus followed by a 2-mg/kg/h infusion until the end of the
surgical procedure) and Group C received normal saline infusion as a placebo.
Results
The VAS scores and fentanyl consumption were significantly lower in Group L compared
with Group C except at 48 h after surgery (p<.05). Total fentanyl consumption, total
FPB, length of HS, and satisfaction scores were also significantly lower in Group
L compared with Group C (p<.05).
Conclusions
Intraoperative systemic infusion of lidocaine decreases pain perception during microdiscectomy,
thus reducing the consumption of opioid and the severity of postoperative pain. This
effect contributes to reduce the length of HS.
Keywords
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Article info
Publication history
Published online: November 11, 2013
Accepted:
September 19,
2013
Received in revised form:
August 29,
2013
Received:
December 26,
2012
Footnotes
This trial is registered with NCT01319682.
FDA device/drug status: Not applicable.
Author disclosures: K-TK: Nothing to disclose. D-CC: Nothing to disclose. J-KS: Nothing to disclose. Y-BK: Nothing to disclose. HK: Nothing to disclose. K-SS: Nothing to disclose. G-JC: Nothing to disclose.
K-TK and D-CC contributed equally to this work.
Identification
Copyright
© 2014 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
