The Spine Journal
Volume 10, Issue 8 , Pages 733-735 , August 2010

Is there an antinociceptive role for peripheral brain-derived neurotrophic factor?

  • Beth A. Winkelstein, PhD

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, 240 Skirkanich Hall, 210 S 33rd St, Philadelphia, PA 19104, USA. Tel.: (215) 573-4589; fax: (215) 573-2071.
    • ,
  • Jeffrey V. Kras, BS

Received 24 May 2010 ,Accepted 1 June 2010.

References 

  1. Winkelstein BA. Mechanisms of central sensitization, neuroimmunology & injury biomechanics in persistent pain: implications for musculoskeletal disorders. J Electromyogr Kinesiol. 2004;14:87–93
  2. Woolf CJ, Mannion RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet. 1999;353:1959–1964
  3. Castro AR, Pinto M, Lima D, Tavares I. Secondary hyperalgesia in the monoarthritic rat is mediated by GABAB and NK1 receptors of spinal dorsal horn neurons: a behavior and c-fos study. Neuroscience. 2006;141:2087–2095
  4. Suzuki R, Rahman W, Rygh LJ, et al. Spinal-supraspinal serotonergic circuits regulating neuropathic pain and its treatment with gabapentin. Pain. 2005;117:292–303
  5. Neubert JK, Mannes AJ, Karai LJ, et al. Perineural resiniferatoxin selectively inhibits inflammatory hyperalgesia. Mol Pain. 2008;4:3
  6. Jeffry JA, Yu S, Sikand P, et al. Selective targeting of TRPV1 expressing sensory nerve terminals in the spinal cord for long lasting analgesia. PLoS One. 2009;4:e7021
  7. Tender GC, Li YY, Cui JG. Brain-derived neurotrophic factor redistribution in the dorsal root ganglia correlates with neuropathic pain inhibition after resiniferatoxin treatment. Spine J. 2010;10:715–720
  8. Schumacher MA. Transient receptor potential channels in pain and inflammation: therapeutic opportunities. Pain Pract. 2010;10:185–200
  9. Brown DC, Iadarola MJ, Perkowski SZ, et al. Physiologic and antinociceptive effects of intrathecal resiniferatoxin in a canine bone cancer model. Anesthesiology. 2005;103:1052–1059
  10. Tender GC, Li Y, Cui J. Vanilloid receptor 1-positive neurons mediate thermal hyperalgesia and tactile allodynia. Spine J. 2008;8:351–358
  11. Kissin I, Bright CA, Bradley EL. Selective and long-lasting neural blockade with resiniferatoxin prevents inflammatory pain hypersensitivity. Anesth Analg. 2002;94:1253–1258
  12. Michael GJ, Averill S, Shorland PJ, et al. Axotomy results in major changes in BDNF expression by dorsal root ganglion cells: BDNF expression in large trkB and trkC cells, in pericellular baskets, and in projections to deep dorsal horn and dorsal column nuclei. Eur J Neurosci. 1999;11:3539–3551
  13. Zhou XF, Chie ET, Deng YS, et al. Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat. Neuroscience. 1999;92:841–853
  14. Coull JAM, Beggs S, Boudreau D, et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005;438:1017–1021
  15. Merighi A, Salio C, Ghirri A, et al. BDNF as a pain modulator. Prog Neurobiol. 2008;85:297–317
  16. McMahon SB. NGF as a mediator of inflammatory pain. Philos Trans R Soc Lond B Biol Sci. 1996;351:431–440
  17. Kerr BJ, Bradbury EJ, Bennett DLH, et al. Brain-derived neurotrophic factor modulates nociceptive sensory inputs and NMDA-evoked responses in the rat spinal cord. J Neurosci. 1999;19:5138–5148
  18. Wang X, Ratnam J, Zou B, et al. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J Neurosci. 2009;29:5508–5515
  19. Mannion RJ, Costigan M, Decosterd I, et al. Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. Proc Natl Acad Sci USA. 1999;96:9385–9390
  20. Pezet S, Malcangio M, McMahon SB. BDNF: a neuromodulator in nociceptive pathways?. Brain Res Brain Res Rev. 2002;40:240–249
  21. Karchewski LA, Gratto KA, Wetmore C, Verge VMK. Dynamic patterns of BDNF expression in injured sensory neurons: differential modulation by NGF and NT-3. Eur J Neurosci. 2002;16:1449–1462
  22. Ohtori S, Takahashi K, Moriya H. Inflammatory pain mediated by a phenotypic switch in brain-derived neurotrophic factor-immunoreactive dorsal root ganglion neurons innervating the lumbar facet joints in rats. Neurosci Lett. 2002;323:129–132
  23. Sweitzer SM, Schubert P, DeLeo JA. Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain. J Pharmacol Exp Ther. 2001;297:1210–1217
  24. Winkelstein BA, Rutkowski MD, Sweitzer SM, et al. Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment. J Comp Neurol. 2001;439:127–139
  25. Woolf CJ, Doubell TP. The pathophysiology of chronic pain—increased sensitivity to low threshold Aβ-fibre inputs. Curr Opin Neurobiol. 1994;4:525–534
  26. Lekan HA, Carlton SM, Coggeshall RE. Sprouting of Aβ fibers into lamina II of the rat dorsal horn in peripheral neuropathy. Neurosci Lett. 1996;208:147–150
  27. Pan HL, Khan GM, Alloway KD, Chen SR. Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action. J Neurosci. 2003;23:2911–2919
  28. Acheson A, Conover JC, Fandl JP, et al. A BDNF autocrine loop in adult sensory neurons prevents cell death. Nature. 1995;374:450–453
  29. Cho HJ, Kim JK, Zhou XF, Rush RA. Increased brain-derived neurotrophic factor immunoreactivity in rat dorsal root ganglia and spinal cord following peripheral inflammation. Brain Res. 1997;764:269–272
  30. Hubbard RD, Martinez JJ, Burdick JA, Winkelstein BA. Controlled release of GDNF reduces nerve root-mediated behavioral hypersensitivity. J Orthop Res. 2009;27:120–127

 FDA device/drug status: not applicable.

 Author disclosures: BAW (research support: investigator salary, Synthes; research support: staff/materials, Synthes; grants, Synthes).

PII: S1529-9430(10)00424-9

doi: 10.1016/j.spinee.2010.06.004

The Spine Journal
Volume 10, Issue 8 , Pages 733-735 , August 2010

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