The Spine Journal
Volume 10, Issue 3 , Pages 191-192 , March 2010

The vertebroplasty affair: the mysterious case of the disappearing effect size

  • Eugene J. Carragee, MD (Editor-in-Chief)

      Affiliations

    • Corresponding Author InformationCorresponding author. Department of Orthopedic Surgery, Stanford Medicine Outpatient Center, Stanford University School of Medicine, 450 Broadway, Mail Code 6342, Redwood City, CA 94063, USA. Tel.: (650) 723-7797; fax: (650) 723-9805.

Received 14 January 2010 ,Accepted 14 January 2010.

References 

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  2. Martin JB, Jean B, Sugiu K, et al. Vertebroplasty: clinical experience and follow-up results. Bone. 1999;25(2 Suppl):11S–15S
  3. Deramond H, Depriester C, Galibert P, Le Gars D. Percutaneous vertebroplasty with polymethylmethacrylate. Technique, indications, and results. Radiol Clin North Am. 1998;36:533–546
  4. Layton KF, Thielen KR, Koch CA, et al. Vertebroplasty, first 1000 levels of a single center: evaluation of the outcomes and complications. AJNR Am J Neuroradiol. 2007;28:683–689
  5. Diamond TH, Champion B, Clark WA. Management of acute osteoporotic vertebral fractures: a nonrandomized trial comparing percutaneous vertebroplasty with conservative therapy. Am J Med. 2003;114:257–265
  6. Rousing R, Andersen MO, Jespersen SM, et al. Percutaneous vertebroplasty compared to conservative treatment in patients with painful acute or subacute osteoporotic vertebral fractures: three-months follow-up in a clinical randomized study. Spine. 2009;34:1349–1354
  7. Buchbinder R, Osborne RH, Ebeling PR, et al. A randomized trial of vertebroplasty for painful osteoporotic vertebral fractures. N Engl J Med. 2009;361:557–568
  8. Kallmes DF, Comstock BA, Heagerty PJ, et al. A randomized trial of vertebroplasty for osteoporotic spinal fractures. N Engl J Med. 2009;361:569–579
  9. Baerlocher MO, Munk PL, Liu DM. Trials of vertebroplasty for vertebral fractures. N Engl J Med. 2009;361:2098;author reply 2099–2100
  10. Clark W, Lyon S, Burnes J. Trials of vertebroplasty for vertebral fractures. N Engl J Med. 2009;361:2097–2098author reply 2099–2100
  11. Lotz JC. Trials of vertebroplasty for vertebral fractures. N Engl J Med. 2009;361:2098;author reply 2099–2100
  12. Parr AM, Wang MY. Vertebroplasty: effective or not?. Neurosurgery. 2009;65:N14
  13. Grey A, Bolland M. Trials of vertebroplasty for vertebral fractures. N Engl J Med. 2009;361:2098–2099author reply 2099–2100
  14. Weinstein JN. Balancing science and informed choice in decisions about vertebroplasty. N Engl J Med. 2009;361:619–6216
  15. Bolster MB. Consternation and questions about two vertebroplasty trials. Cleve Clin J Med. 2010;77:12–16
  16. Carey TS ACP Journal Club. Vertebroplasty was not effective for painful osteoporotic vertebral fractures. Ann Intern Med. 2009;151:JC6–9
  17. Bono CM, Heggeness M, Mick C, Resnick D, Watters WC. North American Spine Society. Newly released vertebroplasty randomized controlled trials: a tale of two trials. Spine J. 2010;10:238–240
  18. Buchbinder R, Kallmes DF. Vertebroplasty: when randomized placebo-controlled trial results clash with common belief. Spine J. 2010;10:241–243

 FDA device/drug status: approved.

 Author disclosures: EJC (stock ownership, Simpirica, Bioassetts, Cytonics; private investment, Simpirica; consulting, Medtronic, Synthes; trips/travel, US Army; scientific advisory board, Intrinsic Orthopedics, Cytonics; other office, Bioassetts; grants, AO Foundation; fellowship support, Depuy Spine; other, orthopedic surgeon).

PII: S1529-9430(10)00038-0

doi: 10.1016/j.spinee.2010.01.002

The Spine Journal
Volume 10, Issue 3 , Pages 191-192 , March 2010

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