The Spine Journal
Volume 9, Issue 7 , Pages 530-536 , July 2009

Thromboprophylaxis in spinal trauma surgery: consensus among spine trauma surgeons

Received 27 September 2008 ,Accepted 17 January 2009.

References 

  1. McCartney J. Pulmonary embolism following trauma. 1934;709
  2. Brach BB, Moser KM, Cedar L, et al. Venous thrombosis in acute spinal cord paralysis. J Trauma. 1977;17:289–292
  3. Geerts WH, Code KI, Jay RM, et al. A prospective study of venous thromboembolism after major trauma. N Engl J Med. 1994;331:1601–1606
  4. Myllynen P, Kammonen M, Rokkanen P, et al. Deep venous thrombosis and pulmonary embolism in patients with acute spinal cord injury: a comparison with nonparalyzed patients immobilized due to spinal fractures. J Trauma. 1985;25:541–543
  5. Petaja J, Myllynen P, Rokkanen P, Nokelainen M. Fibrinolysis and spinal injury. Relationship to post-traumatic deep vein thrombosis. Acta Chir Scand. 1989;155(4–5):241–246
  6. Rossi EC, Green D, Rosen JS, et al. Sequential changes in factor VIII and platelets preceding deep vein thrombosis in patients with spinal cord injury. Br J Haematol. 1980;45:143–151
  7. DeVivo MJ, Krause JS, Lammertse DP. Recent trends in mortality and causes of death among persons with spinal cord injury. Arch Phys Med Rehabil. 1999;80:1411–1419
  8. Waring WP, Karunas RS. Acute spinal cord injuries and the incidence of clinically occurring thromboembolic disease. Paraplegia. 1991;29:8–16
  9. Watson N. Anticoagulant therapy in the treatment of venous thrombosis and pulmonary embolism in acute spinal injury. Paraplegia. 1974;12:197–201
  10. Haas S. Deep vein thrombosis: beyond the operating table. Orthopedics. 2000;23(6 Suppl):s629–s632
  11. Heit JA. Low-molecular-weight heparin: the optimal duration of prophylaxis against postoperative venous thromboembolism after total hip or knee replacement. Thromb Res. 2001;101:V163–V173
  12. Heit JA, Silverstein MD, Mohr DN, et al. Risk factors for deep vein thrombosis and pulmonary embolism: a population-based case-control study. Arch Intern Med. 2000;160:809–815
  13. Ferree BA, Stern PJ, Jolson RS, et al. Deep venous thrombosis after spinal surgery. Spine. 1993;18:315–319
  14. Ferree BA, Wright AM. Deep venous thrombosis following posterior lumbar spinal surgery. Spine. 1993;18:1079–1082
  15. Leslie IJ, Dorgan JC, Bentley G, Galloway RW. A prospective study of deep vein thrombosis of the leg in children on halo-femoral traction. J Bone Joint Surg Br. 1981;63:168–170
  16. Smith MD, Bressler EL, Lonstein JE, et al. Deep venous thrombosis and pulmonary embolism after major reconstructive operations on the spine. A prospective analysis of three hundred and seventeen patients. J Bone Joint Surg Am. 1994;76:980–985
  17. Uden A. Thromboembolic complications following scoliosis surgery in Scandinavia. Acta Orthop Scand. 1979;50:175–178
  18. Bettmann MA, Paulin S. Leg phlebography: the incidence, nature and modification of undesirable side effects. Radiology. 1977;122:101–104
  19. Ferree BA. Deep venous thrombosis following lumbar laminotomy and laminectomy. Orthopedics. 1994;17:35–38
  20. Francis CW, Pellegrini VD, Marder VJ, et al. Prevention of venous thrombosis after total hip arthroplasty. Antithrombin III and low-dose heparin compared with dextran 40. J Bone Joint Surg Am. 1989;71:327–335
  21. Guyer RD, Booth RE, Rothman RH. The detection and prevention of pulmonary embolism in total hip replacement. A study comparing aspirin and low-dose warfarin. J Bone Joint Surg Am. 1982;64:1040–1044
  22. Harris WH, Athanasoulis CA, Waltman AC, Salzman EW. Prophylaxis of deep-vein thrombosis after total hip replacement. Dextran and external pneumatic compression compared with 1.2 or 0.3 gram of aspirin daily. J Bone Joint Surg Am. 1985;67:57–62
  23. Hartman JT, Pugh JL, Smith RD, et al. Cyclic sequential compression of the lower limb in prevention of deep venous thrombosis. J Bone Joint Surg Am. 1982;64:1059–1062
  24. Rokito SE, Schwartz MC, Neuwirth MG. Deep vein thrombosis after major reconstructive spinal surgery. Spine. 1996;21:853–858discussion 9
  25. Valladares JB, Hankinson J. Incidence of lower extremity deep vein thrombosis in neurosurgical patients. Neurosurgery. 1980;6:138–141
  26. West JL, Anderson LD. Incidence of deep vein thrombosis in major adult spinal surgery. Spine. 1992;17(8 Suppl):S254–S257
  27. Audibert G, Faillot T, Vergnes MC, et al. Thromboprophylaxis in elective spinal surgery and spinal cord injury, Ann Fr Anesth Reanim. 2005;24:928–934
  28. Comerota AJ, Katz ML, White JV. Why does prophylaxis with external pneumatic compression for deep vein thrombosis fail?. Am J Surg. 1992;164:265–268
  29. Green D, Rossi EC, Yao JS, et al. Deep vein thrombosis in spinal cord injury: effect of prophylaxis with calf compression, aspirin, and dipyridamole. Paraplegia. 1982;20:227–234
  30. Agnelli G, Piovella F, Buoncristiani P, et al. Enoxaparin plus compression stockings compared with compression stockings alone in the prevention of venous thromboembolism after elective neurosurgery. N Engl J Med. 1998;339:80–85
  31. Agu O, Hamilton G, Baker D. Graduated compression stockings in the prevention of venous thromboembolism. Br J Surg. 1999;86:992–1004
  32. Amaragiri SV, Lees TA. Elastic compression stockings for prevention of deep vein thrombosis. Cochrane Database Syst Rev. 2000;(3):CD001484
  33. Lassen MR, Borris LC, Christiansen HM, et al. Prevention of thromboembolism in 190 hip arthroplasties. Comparison of LMW heparin and placebo. Acta Orthop Scand. 1991;62:33–38
  34. Merli GJ, Crabbe S, Doyle L, et al. Mechanical plus pharmacological prophylaxis for deep vein thrombosis in acute spinal cord injury. Paraplegia. 1992;30:558–562
  35. Nurmohamed MT, van Riel AM, Henkens CM, et al. Low molecular weight heparin and compression stockings in the prevention of venous thromboembolism in neurosurgery. Thromb Haemost. 1996;75:233–238
  36. Ramos R, Salem BI, De Pawlikowski MP, et al. The efficacy of pneumatic compression stockings in the prevention of pulmonary embolism after cardiac surgery. Chest. 1996;109:82–85
  37. Torngren S. Low dose heparin and compression stockings in the prevention of postoperative deep venous thrombosis. Br J Surg. 1980;67:482–484
  38. Wille-Jorgensen P, Hauch O, Dimo B, et al. Prophylaxis of deep venous thrombosis after acute abdominal operation. Surg Gynecol Obstet. 1991;172:44–48
  39. Wille-Jorgensen P, Thorup J, Fischer A, et al. Heparin with and without graded compression stockings in the prevention of thromboembolic complications of major abdominal surgery: a randomized trial. Br J Surg. 1985;72:579–581
  40. Prevention of thromboembolism in spinal cord injury. Consortium for Spinal Cord Medicine. J Spinal Cord Med. 1997;20:259–283
  41. Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133(6 Suppl):381S–453S
  42. Geerts WH, Pineo GF, Heit JA, et al. Prevention of venous thromboembolism: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004;126(3 Suppl):338S–400S
  43. Consortium for Spinal Cord Medicine . Early acute management of adults with acute spinal cord injury: a clinical practice guideline for health-care professionals. Spinal Cord Medicine. 2007;37–39
  44. Ploumis A, Ponnappan R, Sarbello J, et al. Thromboprophylaxis in traumatic and elective spinal surgery: analysis of questionnaire response and current practice of spine trauma surgeons. Spine, under review.
  45. Ploumis A PR, Patel R, Bessey J, et al. Thrombophylaxis in patients with acute spinal injuries and elective spinal surgery: an evidence-based analysis. J Bone Joint Surg Am, revision submitted.
  46. Eriksson BI, Kalebo P, Anthymyr BA, et al. Prevention of deep-vein thrombosis and pulmonary embolism after total hip replacement. Comparison of low-molecular-weight heparin and unfractionated heparin. J Bone Joint Surg Am. 1991;73:484–493
  47. Nurmohamed MT, Rosendaal FR, Buller HR, et al. Low-molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis. Lancet. 1992;340:152–156
  48. Jones T, Ugalde V, Franks P, et al. Venous thromboembolism after spinal cord injury: incidence, time course, and associated risk factors in 16,240 adults and children. Arch Phys Med Rehabil. 2005;86:2240–2247
  49. Silver JR. The prophylactic use of anticoagulant therapy in the prevention of pulmonary emboli in one hundred consecutive spinal injury patients. Paraplegia. 1974;12:188–196
  50. Naso F. Pulmonary embolism in acute spinal cord injury. Arch Phys Med Rehabil. 1974;55:275–278
  51. Perkash A. Experience with the management of deep vein thrombosis in patients with spinal cord injury. Part II: a critical evaluation of the anticoagulant therapy. Paraplegia. 1980;18:2–14
  52. Spinal Cord Injury Tauma Invastigators . Prevention of venous thromboembolism in the rehabilitation phase after spinal cord injury: prophylaxis with low-dose heparin or enoxaparin. J Trauma. 2003;54:1111–1115
  53. Perkash A, Prakash V, Perkash I. Experience with the management of thromboembolism in patients with spinal cord injury: Part I. Incidence, diagnosis and role of some risk factors. Paraplegia. 1978;16:322–331
  54. Johns JS, Nguyen C, Sing RF. Vena cava filters in spinal cord injuries: evolving technology. J Spinal Cord Med. 2006;29:183–190

 FDA device/drug status: not applicable.

 Author disclosures: ARV (royalties: Depuy Spine, Biomet Spine, Globus, Medtronic, K2M, Aesculap; stock ownership: K2M, Cytonics, Disk Motion Technology, Zygoloc, Progressive Spinal Technology, Computational Dynamics, Stout Medical, Bonovo Orthopaedics, Electrocure, Vertiflex, Flagship Surgical, In vivo, Pearl Diver, Small Bone Innovations, Neucore, Crosscurrent, Vertilink, Orthovita, Syndicom, Biomerix, Spinemark, Paradigm Spine, Spinology, Vertebron, Replication Medica, Breakaway Imaging Cross Tree Medical, Globus; consulting: Depuy Spine, Osteotech, Othrofix, Vertiflex, Vertebron, Stryker Spine, K2M, Medtronic, AO Spine; research: AO Spine, Medtronic).

PII: S1529-9430(09)00048-5

doi: 10.1016/j.spinee.2009.01.008

The Spine Journal
Volume 9, Issue 7 , Pages 530-536 , July 2009