The Spine Journal
Volume 3, Issue 1 , Pages 63-67, January 2003

Substance P–containing nerves within the human vertebral body:☆☆☆

an immunohistochemical study of the basivertebral nerve

  • Christian Fras, MD

      Affiliations

    • St. Luke's Roosevelt Hospital, 36 West 60th Street, New York, NY 10023, USA
    • ,
  • Philip Kravetz, MD

      Affiliations

    • Irving Orthopedics, 2120 North MacArthur Boulevard, Irving, TX, 75061, USA
    • ,
  • Dina R Mody, MD

      Affiliations

    • Baylor College of Medicine, 6560 Fannin Street, Suite 1900, Houston, TX 77030, USA
    • ,
  • Michael H Heggeness, MD, PhD

      Affiliations

    • Corresponding Author InformationCorresponding author. Baylor College of Medicine, 6560 Fannin Street, Suite 1900, Houston, TX 77030, USA. Tel.: (713) 986-5730; fax: (713) 986-5731.
    • Baylor College of Medicine, 6560 Fannin Street, Suite 1900, Houston, TX 77030, USA

Received 28 February 2002; accepted 8 July 2002.

Abstract 

Background content: The basivertebral nerve provides innervation to the trabecular bone of the vertebral body. The function of this nerve is not known.

Purpose: The study was undertaken to better define the anatomic origin of this intraosseous nerve and to determine if this nerve contains substance P. Methods: The basivertebral nerve, which enters the vertebral body by means of the large posterior vascular foramen was studied anatomically by dissection and then histologically characterized. Sixty-two specimens of the basivertebral nerve were harvested from within the bone by microscopically aided dissection. Specimens were harvested from cervical, thoracic and lumbar vertebrae. These specimens were then stained for the presence of protein S-100 and substance P. Results: All 62 specimens stained positively for both S-100 and substance P. Conclusion: The presence of substance P within these nerves is strong evidence that these nerves have the potential to transmit signals of nociception. The basivertebral nerve may play a role in some forms of clinical back and neck pain.

Keywords:  Basivertebral nerve, Substance P, Back pain, Intraosseous nerve, Nociception

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☆ FDA device/drug status: not applicable.

☆☆ Nothing of value received from a commercial entity related to this research.

PII: S1529-9430(02)00455-2

The Spine Journal
Volume 3, Issue 1 , Pages 63-67, January 2003

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