The Spine Journal
Volume 3, Issue 1 , Pages 11-18 , January 2003

Role of calcineurin in calcium-mediated hypoxic injury to white matter

  • Lloyd W Mobley III, MD
  • ,
  • Sandeep K Agrawal, PhD

      Affiliations

    • Corresponding Author InformationCorresponding author. Section of Neurosurgery, 982035 Nebraska Medical Center, Omaha, NE 68198-2035, USA. Tel: (402) 559-4567; fax: (402) 559-7779.

Received 2 March 2002 ,Accepted 4 June 2002.

References 

  1. Agrawal SK, Fehlings MG. Role of NMDA and non-NMDA ionotropic glutamate receptors in traumatic spinal cord axonal injury. J. Neurosci. 1997;17:1055–1063
  2. Li S, Stys PK. Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter. J. Neurosci. 2000;20:1190–1198
  3. Wrathall JR, Choiniere D, Teng YD. Dose-dependent reduction of tissue loss and functional impairment after spinal cord trauma with the AMPA/kainate antagonist NBQX. J Neurosci. 1994;14:6598–6607
  4. Lev-Ram V, Grinvald A. Ca2+- and K+-dependent communication between central nervous system myelinated axons and oligodendrocytes revealed by voltage-sensitive dyes. Proc Nat Acad Sci USA. 1986;83:6651–6655
  5. Fern R, Ransom BR, Waxman SG. Voltage-gated calcium channels in CNS white matter (role in anoxic injury). J Neurophysiol. 1995;74:369–377
  6. MacVicar BA. Voltage-dependent calcium channels in glial cells. Science. 1984;226:1345–1347
  7. Thorell WE, Leibrock LG, Agrawal SK. Role of RyRs and IP3 receptors after traumatic injury to spinal cord white matter. J Neurotrauma. 2002;19:335–342
  8. Tomes DJ, Agrawal SK. Role of KB-R7943 Na+-Ca2+ exchanger after hypoxic/ischemic injury to spinal cord white matter. Spine J. 2002;2(1):35–40
  9. Liu J, Farmer JD, Lane WS, Friedman J, Weissman I, Schreiber SL. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991;66:807–815
  10. Shibasaki F, McKeon F. Calcineurin functions in Ca2+-activated cell death in mammalian cells. J Cell Biol. 1995;131:735–743
  11. Wang HG, Pathan N, Ethell IM, et al.  Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD. Science. 1999;284:339–343
  12. Sharkey J, Butcher SP. Immunophilins mediate the neuroprotective effects of FK-506 in focal cerebral ischaemia. Nature. 1994;371:336–339
  13. Uchino H, Elmer E, Uchino K, Lindvall O, Siesjo BK. Cyclosporin A dramatically ameliorates CA1 hippocampal damage following transient forebrain ischaemia in the rat. Acta Physiol Scand. 1995;155:469–471
  14. Stys PK. Anoxic and ischemic injury of myelinated axons in CNS white matter (from mechanistic concepts to therapeutics). J Cereb Blood Flow Metab. 1998;18:2–25
  15. Agrawal SK, Fehlings MG. Mechanisms of secondary injury to spinal cord axons in vitro (role of Na+, Na+–K+ ATPase, the Na+–H+ exchanger, and the Na+–Ca2+ exchanger). J Neurosci. 1996;16:545–552
  16. Agrawal SK, Fehlings MG. The effect of sodium channel blocker QX-314 on recovery after acute spinal cord injury. J Neurotrauma. 1997;14:81–88
  17. Agrawal SK, Nashmi R, Fehlings MG. Role of L- and N-type calcium channels in the pathophysiology of traumatic spinal cord white matter injury. Neuroscience. 2000;990:179–188
  18. Schanne FAX, Kane AB, Young EA, Farber JL. Calcium dependence of toxic cell death (a final common pathway). Science. 1979;206:700–702
  19. Farooqui AA, Horrocks LA. Excitatory amino acid receptors, neural membrane phospholipid metabolism and neurological disorders. Brain Res Rev. 1991;16:171–191
  20. Roberts-Lewis JM, Siman R. Spectrin proteolysis in the hippocampus (a biochemical marker for neuronal injury and neuroprotection). Ann NY Acad Sci. 1993;679:78–86
  21. Siman R, Noszek C, Kegerise C. Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage. J Neurosci. 1989;9:1579–1590
  22. Favaron M, Manev H, Siman R, et al.  Down-regulation of protein kinase C protects cerebellar granule neurons in primary culture from glutamate-induced neuronal death. Proc Nat Acad Sci USA. 1990;87:1983–1987
  23. Zivin JA, Kochhar A, Saitoh T. Protein phosphorylation during ischemia. Stroke. 1990;21:III-117–III-121 [suppl III]
  24. McCaslin PP, Smith TH. Quisqualate, high calcium concentration and zero-chloride prevent kainate-induced toxicity of cerebellar granule cells. Eur J Pharmacol. 1988;152:341–346
  25. Roberts-Lewis JM, March VR, Zhao Y, Vaught JL, Siman R, Lewis ME. Aurintricarboxylic acid protects hippocampal neurons from NMDA- and ischemia-induced toxicity in vivo. J Neurochem. 1993;61:378–381
  26. Tymianski M, Tator CH. Normal and abnormal calcium homeostasis in neurons (a basis for the pathophysiology of traumatic and ischemic central nervous system injury). Neurosurgery. 1996;38:1176–1195
  27. Brillantes AB, Ondrias K, Scott A, et al.  Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein. Cell. 1994;77:513–523
  28. Cameron AM, Steiner JP, Sabatini DM, Kaplin AI, Walensky LD, Snyder SH. Immunophilin FK506-binding protein associated with inositol 1,4,5-triphosphate receptor modulates calcium flux. Proc Nat Acad Sci USA. 1995;92:1784–1788
  29. Franzini-Armstrong C, Nunzi G. Junctional feet and membrane particles in the triad of a fast twitch muscle fiber. J Muscle Res. 1983;4:233–252
  30. Timmerman AP, Ogunbumni E, Freund E, Wiederrecht G, Marks AR, Fleischer S. The calcium release channel of sarcoplasmic reticulum is modulated by FK506-binding protein. Dissociation and reconstitution of FKBP12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum. J Biol Chem. 1993;268:22992–22999
  31. Kanoh S, Kondo M, Tamaoki J, et al.  Effect on FK-506 on ATP- induced intracellular calcium oscillations in cow tracheal epithelium. Am J Physiol. 1999;276:L891–L899
  32. Bultynck G, DeSmet P, Rossi D, et al.  Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-triphosphate receptor. Biochem J. 2001;354:413–422
  33. Snyder SH, Lai MM, Burnett PE. Immunophilins in the nervous system. Neuron. 1998;21:283–294
  34. Dawson VL, Dawson TM, Bartley DA, Uhl GR, Snyder SH. Mechanism of nitric oxide–mediated neurotoxicity in primary brain cultures. J Neurosci. 1993;13:2651–2661
  35. Shibasaki F, Hallin U, Uchino H. Calcineurin as a multifunctional regulator. J Biochem. 2002;131:1–15
  36. Springer JE, Azbill RD, Nottingham SA, Kennedy SE. Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury. J Neurosci. 2000;20:7246–7251

 FDA device/drug status: not applicable

☆☆ Nothing of value received from a commercial entity related to this research.

PII: S1529-9430(02)00442-4

The Spine Journal
Volume 3, Issue 1 , Pages 11-18 , January 2003